Min Yuanzeng
Special-term Professor
Phone: 86-551-63601817
E-mail: minyz@ustc.edu.cn
Personal Profile
April 2019 - Present: Special-term Professor of the Department of Chemistry of the University of Science and Technology of China
September 2018 - March 2019: Special-term Researcher of the Department of Chemistry of the University of Science and Technology of China
2017 - 2018: Research Scholar of UNC Lineberger Comprehensive Cancer Center of University of North Carolina at Chapel Hill (3D printing material processing and biomedical applications, collaborating with Professor Joseph DeSimone, an academician of the National Academy of Engineering, American Academy of Arts and Sciences, and National Academy of Sciences)
2014 - 2017: Research Scholar of School of Medicine (UNC Lineberger Comprehensive Cancer Center) and Centers of Cancer Nanotechnology Excellence of University of North Carolina at Chapel Hill (Nanotechnology related to radiotherapy sensitization and tumor immunotherapy, collaborating with Professor Andrew Wang, an AIMBE fellow and clinical radiotherapist, with the co-mentor of Professor Jonathan S. Serody, a clinical doctor)
2012 - 2014: Research Fellow of the Department of Chemistry and Biochemistry of Nanyang Technological University (Biomolecular imaging, collaborating with Professor Bengang Xing)
2008 - 2012: Ph.D. in Inorganic Chemistry (discipline evaluation: A+) from the University of Science and Technology of China
Min Yuanzeng received a Ph.D. in Inorganic Chemistry from the University of Science and Technology of China. He once worked at the Department of Chemistry and Biochemistry of Nanyang Technological University as a Research Fellow, and at the School of Medicine and Carolina Institute for Nanomedicine of University of North Carolina at Chapel Hill as a Research Scholar. In 2018, he joined the University of Science and Technology of China to teach and conduct interdisciplinary research, including undergraduate and graduate courses. His main research areas include nanotechnology related to metal drugs, nanomedicine, and immune diseases. He has published over 20 papers in prestigious international journals such as Nature Nanotechnology, Chemical Reviews, Angewandte Chemie International Edition, ACS Nano, and Biomaterials about his interdisciplinary research in medicine, chemistry, and materials. Regarding his research achievements, he has been granted one Chinese invention patent and applied for two US patents (one of which has received investment from Fosun Group). He once received the President’s Excellent Award of Chinese Academy of Sciences.
Research Directions:
Inorganic Chemistry/Chemical Biology/Nano Biomedicine
Recent research topics:
1. Nanotechnology related to tumor immunotherapy
2. Biomolecular imaging
3. Tumor radiotherapy sensitization
4. 3D printing materials and their applications in biomedical engineering
Students interested in our research directions are welcome to contact and join our group for degree studies and postdoctoral research!
Teaching:
Inorganic Chemistry (Undergraduate course)
Chemical Biology Experiment (Undergraduate course)
Chemical Biology (Graduate course)
Awards and Honors:
President’s Excellent Award of Chinese Academy of Sciences (2012)
National Talent Program (Priority Funding)
Ongoing Projects:
National Natural Science Foundation of China
Research Start-Up Funds of the University of Science and Technology of China
Joint Fund for New Medicine of USTC (Key Direction Project and Innovative Team Project)
Academic Services:
Advisory Board Member of WIREs Nanomedicine & Bionanotechnology
Guest Editor of BMJ Oncology
Reviewer for journals including Science Advances, Advanced Materials, Advanced Healthcare Materials, Small, JACS Au, Nano Today, Acta Biomaterialia, Nanomedicine NBM, Nanoscale, and Bioactive Materials
Publications and Monographs:
(# denotes co-first author, * denotes corresponding author)
https://scholar.google.com/citations?hl=zh-CN&user=eZMV-dEAAAAJ&view_op=list_works&sortby=pubdate
1. Yuanzeng Min, Kyle C. Roche, Shaomin Tian, Michael J. Eblan, Karen P.McKinnon, Joseph M. Caster, Shengjie Chai, Laura E. Herring, Longzhen Zhang, Tian Zhang, Joseph M. DeSimone, Joel E. Tepper, Benjamin G. Vincent, Jonathan S. Serody and Andrew Z. Wang*. Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy. Nature nanotechnology, 2017, 12 (9), 877-882.
2. Chen Bo; Huang Ruijie; Zeng Wei; Wang Wei*; Min Yuanzeng*; Nanocodelivery of an NIR photothermal agent and an acid-responsive TLR7 agonist prodrug to enhance cancer photothermal immunotherapy and the abscopal effect, Biomaterials, 2023, 305.
3. Huang Ruijie; Zhou Peijie; Chen Bo; Zhu Yang*; Chen Xiaoyuan*; Min Yuanzeng*; Stimuli-Responsive Nanoadjuvant Rejuvenates Robust Immune Responses to Sensitize Cancer Immunotherapy, ACS Nano, 2023, 17(21): 21455-21469.
4. Chen Guiyuan; Li Xiangxia; Li Rui; Wu Kecheng; Lei Zhouhang; Dai Ruike; Roche Kyle; Wang Andrew Z.; Min Yuanzeng*; Chemotherapy-Induced Neoantigen Nanovaccines Enhance Checkpoint Blockade Cancer Immunotherapy, ACS Nano, 2023, 17(19): 18818-18831.
5. Li Rui; Hao Yuhao; Min Yuanzeng*; Platinum-Based Twin Drug Modulates Tumor-Infiltrating Immune Cells to Improve Immune Checkpoint Blockade Therapy, Journal of Medicinal Chemistry, 2023, 66(19): 13607-13621.
6. Hao Yuhao; Li Rui; Pan Wen; Tian Shaomin; Min Yuanzeng*; Platinum Twin and Triplet Drugs Improve Chemoimmunotherapy, Journal of Medicinal Chemistry, 2023, 66(17): 12225-12236.
7. Li Rui; Hao Yuhao; Roche Kyle; Chen Guiyuan; Pan Wen; Wang Andrew Z.; Min Yuanzeng*; Chemotherapy-induced nanovaccines implement immunogenicity equivalence for improving cancer chemoimmunotherapy, Biomaterials, 2023, 301: 122290.
8. Li Rui; Hao Yuhao; Pan Wen; Wang Wei*; Min Yuanzeng*; Monophosphoryl lipid A-assembled nanovaccines enhance tumor immunotherapy, Acta Biomaterialia, 2023, 171: 482-494.
9. Su Lanhong; Pan Wen; Li Xiangxia; Zhou Xingyu; Ma Xiaopeng*; Min Yuanzeng*; Utilizing chemotherapy-induced tumor RNA nanoparticles to improve cancer chemoimmunotherapy, Acta Biomaterialia, 2023, 158(1): 698-707.
10. Su Lanhong; Hao Yuhao; Li Rui; Pan Wen; Ma Xiaopeng*; Weng Jianping; Min Yuanzeng*; Red blood cell-based vaccines for ameliorating cancer chemoimmunotherapy, Acta Biomaterialia, 2022, 154: 401-411.